Novel methods for predicting clinical outcome in neonates from clinical electroencephalography recordings

......................................................................................................................................... 23 1.1 The neonatal brain: conception to postnatal development ........................................ 24 1.1.1 Formation of the brain............................................................................................... 24 1.1.2 Neonatal cortical connections ................................................................................... 25 1.2 Brief epidemiology of neonatal encephalopathy ......................................................... 29 1.2.1 Birth asphyxia and hypoxic ischemic encephalopathy .............................................. 29 1.2.2 Preterm brain injury: risk factors and incidence....................................................... 30 1.3 Common measures in neonatal brain monitoring ...................................................... 33 1.3.1 Neuroprotective care for at-risk infants: full-term hypoxia and preterm birth ........ 33 1.3.2 Continuous Electroencephalography monitoring of neonates ................................. 34 1.4 Insights from neuroscience ........................................................................................... 36 1.5 Research aims and hypotheses .................................................................................... 37 1.6 Organization of thesis chapters ................................................................................... 38 2.0 Review of selected literature ......................................................................................... 41 Abstract .......................................................................................................................................... 41......................................................................................................................................... 41 2.1 Full-term hypoxia and Burst Suppression .................................................................. 42 2.1.1 Pathophysiology of HIE .............................................................................................. 42 2.1.2 Common EEG features in burst suppression ............................................................. 43 2.1.3 Quantification of EEG features from neonatal burst suppression ........................... 45 2.2 Cortical activity in the early preterm ......................................................................... 49